Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study
Identifieur interne : 000D03 ( Main/Exploration ); précédent : 000D02; suivant : 000D04Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study
Auteurs : Roberto Ceravolo [Italie] ; Angelo Antonini [Italie] ; Duccio Volterrani [Italie] ; Carlo Rossi [Italie] ; Lorenzo Kiferle [Italie] ; Daniela Frosini [Italie] ; Claudio Lucetti [Italie] ; Ioannis U. Isaias [Italie] ; Riccardo Benti [Italie] ; Luigi Murri [Italie] ; Ubaldo Bonuccelli [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-10-30.
English descriptors
Abstract
The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22259
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-10-30">2008-10-30</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2049">2049</biblScope><biblScope unit="page" to="2054">2054</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8F0057EF5881D49283FA88A7172428481992F9A4</idno><idno type="DOI">10.1002/mds.22259</idno><idno type="ArticleID">MDS22259</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>SPECT</term><term>dopamine transporter</term><term>isolated tremors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name></noRegion><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><name sortKey="Frosini, Daniela" sort="Frosini, Daniela" uniqKey="Frosini D" first="Daniela" last="Frosini">Daniela Frosini</name><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><name sortKey="Kiferle, Lorenzo" sort="Kiferle, Lorenzo" uniqKey="Kiferle L" first="Lorenzo" last="Kiferle">Lorenzo Kiferle</name><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name><name sortKey="Murri, Luigi" sort="Murri, Luigi" uniqKey="Murri L" first="Luigi" last="Murri">Luigi Murri</name><name sortKey="Rossi, Carlo" sort="Rossi, Carlo" uniqKey="Rossi C" first="Carlo" last="Rossi">Carlo Rossi</name><name sortKey="Volterrani, Duccio" sort="Volterrani, Duccio" uniqKey="Volterrani D" first="Duccio" last="Volterrani">Duccio Volterrani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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